Powder densification. 2. Viscoelastic material properties in modeling the uniaxial compaction of powders

J Pharm Sci. 1998 Aug;87(8):909-16. doi: 10.1021/js9801079.

Abstract

A micromechanical model for predicting the densification of particulate matter under hydrostatic loading was developed to account for the time-dependent response of materials to applied loads. Viscoelastic material response used in the analysis was based upon a standard three-parameter rheological model. Compaction data under closed die conditions were collected using an Instron analyzer for different rates of applied load. Densification during the loading phase of PMMA/coMMA powder, a pharmaceutical polymeric coating material, was well predicted by the proposed algorithm, which contrasts with the prediction implied through a static indentation model. Secondary factors which affect compaction such as die-wall friction are also briefly discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Chemistry, Pharmaceutical / statistics & numerical data*
  • Drug Compounding
  • Elasticity
  • Hardness Tests
  • Models, Theoretical
  • Particle Size
  • Polymers
  • Polymethyl Methacrylate
  • Powders*
  • Pressure
  • Viscosity

Substances

  • Polymers
  • Powders
  • Polymethyl Methacrylate