A broader overview of the essential differences and overlap in the histopathology and clinical presentation of giant cell containing lesions are discussed. This is an attempt to eliminate some confusions attendant to their diagnosis and possible prognosis. These lesions occur both intraosseously and extraosseously. Langhans' type giant cells have been shown not to be an exclusive preserve of tuberculoid granulomas but also of giant cell lesions. The osteoclast like lesions with the exception of giant cell tumour (GCT) are treated by local curettage while the latter is treated by radical resection.