Abstract
A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structures of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Cnidaria / chemistry*
-
Drug Screening Assays, Antitumor
-
Female
-
Humans
-
Indonesia
-
Magnetic Resonance Spectroscopy
-
Ovarian Neoplasms / drug therapy
-
Secosteroids / isolation & purification*
-
Secosteroids / pharmacology
-
Tumor Cells, Cultured
Substances
-
3,7,11-trihydroxy-5,6-epoxy-9,11-secogorgostan-9-one
-
Antineoplastic Agents
-
Secosteroids