Cellular basis for the T wave of the electrocardiogram

Nature. 1976 Aug 19;262(5570):657-61. doi: 10.1038/262657a0.

Abstract

Differences in action potential duration in different regions of the mammalian ventricle are not systematically present when quiescent tissue is first stimulated, but develop rapidly during repetitive activity. The effects of ouabain and temperature suggest the involvement of the Na+-K+ exchange pump.

MeSH terms

  • Action Potentials* / drug effects
  • Animals
  • Biological Transport
  • Cold Temperature
  • Electrocardiography*
  • Heart / physiology*
  • Heart Ventricles / anatomy & histology
  • Myocardial Contraction*
  • Myocardium / metabolism
  • Ouabain / pharmacology
  • Potassium / metabolism
  • Sheep
  • Sodium / metabolism
  • Time Factors

Substances

  • Ouabain
  • Sodium
  • Potassium