Wave propagation mediated by GABAB synapse and rebound excitation in an inhibitory network: a reduced model approach

Z Chen; B Ermentrout; X J Wang

doi:10.1023/a:1008878310900

Wave propagation mediated by GABAB synapse and rebound excitation in an inhibitory network: a reduced model approach

J Comput Neurosci. 1998 Mar;5(1):53-69. doi: 10.1023/a:1008878310900.

Authors

Z Chen¹, B Ermentrout, X J Wang

Affiliation

¹ Department of Mathematics, University of Pittsburgh, PA 15260, USA.

PMID: 9540049
DOI: 10.1023/a:1008878310900

Abstract

A reduction method is used to analyze a spatially structured network model of inhibitory neurons. This network model displays wave propagation of postinhibitory rebound activity, which depends on GABAB synaptic interactions among the neurons. The reduced model allows explicit solutions for the wavefronts and their velocity as a function of various parameters, such as the synaptic coupling strength. These predictions are shown to agree well with the numerical simulations of the conductance-based biophysical model.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Electric Conductivity
Models, Neurological*
Neural Inhibition / physiology*
Receptors, GABA-B / physiology*
Sleep / physiology
Synapses / chemistry*
Synapses / physiology*
Thalamus / chemistry
Thalamus / physiology

Substances

Receptors, GABA-B

Grants and funding

MH53717/MH/NIMH NIH HHS/United States