Abstract
To determine whether Epstein-Barr virus (EBV) constitutes a contributing factor in AIDS and, conversely, whether the human immunodeficiency virus (HIV) alters the course of primary EBV infection in a pediatric population, 62 children born to HIV-infected mothers and prospectively followed were evaluated. EBV infection was documented by EBV-specific serology and polymerase chain reaction and by clinical history. HIV infection status was determined according to the Centers for Disease Control and Prevention pediatric classification system. Demographics from HIV-infected and HIV-uninfected children were comparable. The data suggest that HIV-infected children may acquire primary EBV infection earlier in life. The incidence of accompanying splenomegaly or hepatomegaly (or both) around the time of EBV seroconversion was higher among HIV-infected children than among HIV-uninfected children. In contrast, HIV disease progression and HIV-1 RNA load did not seem to be influenced by primary EBV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / epidemiology*
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AIDS-Related Opportunistic Infections / virology
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Antibodies, Viral / analysis
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Antibodies, Viral / immunology
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Capsid / immunology
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Female
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HIV-1 / genetics
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HIV-1 / immunology
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HIV-1 / isolation & purification
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Hepatomegaly / diagnosis
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Hepatomegaly / epidemiology
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Herpesviridae Infections / diagnosis
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Herpesviridae Infections / epidemiology*
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / immunology
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Herpesvirus 4, Human / isolation & purification
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Humans
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Incidence
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Infant
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Infant, Newborn
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Male
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Polymerase Chain Reaction
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Pregnancy
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Pregnancy Complications, Infectious / virology
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Prospective Studies
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RNA, Viral / isolation & purification
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Splenomegaly / diagnosis
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Splenomegaly / epidemiology
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Tumor Virus Infections / diagnosis
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Tumor Virus Infections / epidemiology*
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Viral Load
Substances
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Antibodies, Viral
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DNA, Viral
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RNA, Viral