Identification of the anthracycline antibiotic 4-O-(beta-D-glucopyranuronosyl)-epsilon-rhodomycinone, produced by Streptomyces ruber JCM3131, as an up-regulator of MHC class-I molecules in B16/BL6 cells

J Antibiot (Tokyo). 1998 Jan;51(1):85-8. doi: 10.7164/antibiotics.51.85.

Authors

Y Komatsu¹, O Takahashi, H Hayashi

Affiliation

¹ Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Saitama, Japan.

PMID: 9531993
DOI: 10.7164/antibiotics.51.85

No abstract available

MeSH terms

Animals
Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Dose-Response Relationship, Drug
Glycosides / chemistry*
Glycosides / isolation & purification*
Glycosides / pharmacology
Histocompatibility Antigens Class I / metabolism*
Magnetic Resonance Spectroscopy
Melanoma, Experimental / immunology
Mice
Naphthacenes / chemistry*
Naphthacenes / isolation & purification*
Naphthacenes / pharmacology
Streptomyces / chemistry*
Up-Regulation

Substances

Antibiotics, Antineoplastic
Glycosides
Histocompatibility Antigens Class I
Naphthacenes
4-O-(glucopyranosyl)-epsilon-rhodomycinone