Derangement of warfarin anticoagulation by miconazole oral gel

Br Dent J. 1998 Jan 24;184(2):68-9. doi: 10.1038/sj.bdj.4809547.

Abstract

The potentiation of the anticoagulant effects of warfarin by miconazole, when used in oral gel form, is described in three patients. The associated morbidity is examined, emphasising the importance of considering this potentially serious interaction when prescribing antifungal agents to patients on oral anticoagulants.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / adverse effects*
  • Antifungal Agents / therapeutic use
  • Blood Coagulation / drug effects
  • Candidiasis, Oral / drug therapy
  • Contusions / chemically induced
  • Drug Interactions
  • Female
  • Gels
  • Humans
  • Male
  • Melena / chemically induced
  • Miconazole / administration & dosage
  • Miconazole / adverse effects*
  • Miconazole / therapeutic use
  • Middle Aged
  • Mouth Diseases / chemically induced
  • Purpura / chemically induced
  • Stomatitis, Denture / drug therapy
  • Stomatitis, Denture / microbiology
  • Warfarin / administration & dosage
  • Warfarin / adverse effects*
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Antifungal Agents
  • Gels
  • Warfarin
  • Miconazole