A total of 299 pancreatic cancer (PC) cases were registered in Chennai during 1982-1993 with an age-adjusted incidence rate (AAR) of 1.0 per 100,000. The present study shows an increasing trend in the risk of PC with an increase in the literacy level among males (P < 0.001). The relative survival rates at 1, 3 and 5 years were 35.7, 14.4 and 6.1%, respectively. Age at diagnosis, sex, religious group and literacy level did not emerge as significant prognostic factors for survival from PC. It is reiterated that emphasis should be placed on primary prevention of pancreatic cancer as opposed to early detection, by controlling the use of tobacco.