Abstract
Energy-linked respiration causes a net movement of Mg2+ between rat heart mitochondria and the ambient medium. When the extramitochondrial concontration of Mg2+ is less that about 2.5 mM the net movement of Mg2+ constitutes an efflux, whereas a net influx of Mg2+ occurs when the external concentration of Mg2+ is greater than this. Both the efflux and the influx are induced to only a very small degree by externally added ATP. Evidence suggests that Pi may be required for the respiration-induced efflux of Mg2+.
MeSH terms
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Adenosine Diphosphate / pharmacology
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Adenosine Triphosphate / pharmacology
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Animals
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Calcium / pharmacology
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Electron Transport
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In Vitro Techniques
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Ketoglutaric Acids / pharmacology
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Magnesium / metabolism*
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Mitochondria, Muscle / metabolism*
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Myocardium / metabolism*
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Oligomycins / pharmacology
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Oxygen Consumption*
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Phosphates / analysis
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Phosphates / pharmacology
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Rats
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Rotenone / pharmacology
Substances
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Ketoglutaric Acids
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Oligomycins
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Phosphates
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Rotenone
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Adenosine Diphosphate
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Adenosine Triphosphate
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Magnesium
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Calcium