For over a quarter of a century, echocardiography has made an unparalleled contribution to clinical cardiology as a major tool for real-time imaging of cardiac dynamics. Echocardiography is widely used to assess cardiac function and provides noninvasive information, which is invaluable for the diagnosis of various disease states. However, despite its numerous advantages echocardiography has remained mostly qualitative and subjective. The continued progress in our understanding of the interaction between ultrasound and tissue has brought about several new developments, which allow quantitative analysis of ultrasound data. Among these new developments are endocardial boundary detection (frequently referred to as acoustic quantification) and color kinesis, which provide a more objective, robust, and convenient evaluation of cardiac and vascular dynamics that embraces multiple clinical applications. This review describes these two techniques, focusing on their current status and the evolving clinical applications.