Abstract
The possible regulation of the expression of uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined in rats. Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues. The effect of T3 was markedly observed in heart, whereas a moderate effect was seen in skeletal muscle and no effect in kidney or liver. These results suggest that UCP2 is a protein that may be involved in the nuclear-mediated effect of T3 on resting metabolic rate in the rat.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Hyperthyroidism / metabolism*
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Hypothyroidism / metabolism*
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Iodide Peroxidase / metabolism
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Ion Channels
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Kidney / metabolism
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Liver / metabolism
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Male
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Membrane Transport Proteins*
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Mitochondrial Proteins*
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Muscle, Skeletal / metabolism
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Myocardium / metabolism*
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Organ Specificity
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Protein Biosynthesis*
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RNA, Messenger / biosynthesis
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Rats
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Rats, Wistar
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Thyroid Gland / physiology*
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Thyroxine / pharmacology*
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Transcription, Genetic / drug effects
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Transcription, Genetic / physiology*
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Triiodothyronine / pharmacology*
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Uncoupling Protein 2
Substances
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Ion Channels
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Membrane Transport Proteins
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Mitochondrial Proteins
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RNA, Messenger
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Ucp2 protein, rat
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Uncoupling Protein 2
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Triiodothyronine
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Iodide Peroxidase
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Thyroxine