Induction of UCP2 mRNA by thyroid hormones in rat heart

FEBS Lett. 1997 Nov 24;418(1-2):171-4. doi: 10.1016/s0014-5793(97)01375-6.

Abstract

The possible regulation of the expression of uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined in rats. Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues. The effect of T3 was markedly observed in heart, whereas a moderate effect was seen in skeletal muscle and no effect in kidney or liver. These results suggest that UCP2 is a protein that may be involved in the nuclear-mediated effect of T3 on resting metabolic rate in the rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hyperthyroidism / metabolism*
  • Hypothyroidism / metabolism*
  • Iodide Peroxidase / metabolism
  • Ion Channels
  • Kidney / metabolism
  • Liver / metabolism
  • Male
  • Membrane Transport Proteins*
  • Mitochondrial Proteins*
  • Muscle, Skeletal / metabolism
  • Myocardium / metabolism*
  • Organ Specificity
  • Protein Biosynthesis*
  • RNA, Messenger / biosynthesis
  • Rats
  • Rats, Wistar
  • Thyroid Gland / physiology*
  • Thyroxine / pharmacology*
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / physiology*
  • Triiodothyronine / pharmacology*
  • Uncoupling Protein 2

Substances

  • Ion Channels
  • Membrane Transport Proteins
  • Mitochondrial Proteins
  • RNA, Messenger
  • Ucp2 protein, rat
  • Uncoupling Protein 2
  • Triiodothyronine
  • Iodide Peroxidase
  • Thyroxine