Two hundred and forty one patients with previous bleeding from esophageal varices caused by liver cirrhosis were treated with fiberoptic endoscopic injection sclerotherapy (EIS). The result was desirable. 217 patients were followed. The mean follow-up time was 63. 15 months. The median time was 58 months. Rebleeding rate was 15.21% (33 cases). The total 5-year survival rate was 59%; patients with Child A, B and C were 65% and 35%, respectively. The mortality rate was 10. 60% (23 cases), among them 12 were caused by rebleeding. EIS is an effective method for preventing from rebleeding. Multiple and periodic injections reduce rebleeding rate. EIS increase the 5-year survi al rate by reducing rebleeding rate.