Abstract
The unicellular flagellate Euglena gracilis was used in order to assess the inhibition of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) mutagenicities, which induce white mutants due to the irreversible loss of chloroplasts. All tested compounds, including o-aminobenzoic acid and p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, sodium salicylate and p-aminosalicylic acid, were not mutagenic per se and inhibited MNNG mutagenicity by at least 50%. The last two compounds inhibited by at least 50% also MNU mutagenicity.
MeSH terms
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4-Aminobenzoic Acid / pharmacology
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Aminosalicylic Acid / pharmacology
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Animals
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Antimutagenic Agents / pharmacology*
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Aspirin / pharmacology
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Chloroplasts / drug effects
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Chloroplasts / genetics
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Euglena gracilis / drug effects*
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Euglena gracilis / genetics*
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Eukaryotic Cells
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Methylnitronitrosoguanidine / toxicity
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Methylnitrosourea / toxicity
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Mutagenicity Tests / methods*
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Mutagens / toxicity*
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Mutation
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Pigmentation / drug effects
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Pigmentation / genetics
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Salicylates / pharmacology
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Salicylic Acid
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Sodium Salicylate / pharmacology
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ortho-Aminobenzoates / pharmacology
Substances
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Antimutagenic Agents
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Mutagens
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Salicylates
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ortho-Aminobenzoates
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anthranilic acid
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Methylnitronitrosoguanidine
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Aminosalicylic Acid
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Methylnitrosourea
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Salicylic Acid
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Aspirin
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4-Aminobenzoic Acid
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Sodium Salicylate