Abstract
DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Intranasal
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Animals
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Antigens, Viral / immunology
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Epitopes / immunology
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HIV Antibodies / biosynthesis*
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HIV-1 / immunology*
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Immunity, Mucosal
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Immunoglobulin A / biosynthesis
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Immunoglobulin G / biosynthesis
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Lymphocyte Activation
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / immunology*
Substances
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Antigens, Viral
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Epitopes
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HIV Antibodies
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Immunoglobulin A
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Immunoglobulin G
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Vaccines, DNA