Abstract
We report on a case of methotrexate (MTX) intoxication occurring in a 19-year-old man treated for a leukemia. Exchange-transfusion (ET) was performed in attempt to remove the MTX from the body. This exchange-transfusion was unable to decrease the MTX plasma concentration. This inefficacy of ET in MTX intoxication is in contradiction with previously reported recommendations. However, this result is easily explained by MTX pharmacokinetics parameters.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / therapy
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Adult
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Antidotes / therapeutic use
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / poisoning*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Diuretics / therapeutic use
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Drug Overdose / etiology
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Drug Overdose / therapy
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Exchange Transfusion, Whole Blood*
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Furosemide / therapeutic use
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Humans
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Leucovorin / therapeutic use
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Male
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Methotrexate / administration & dosage
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Methotrexate / blood
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Methotrexate / poisoning*
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Pancytopenia / chemically induced
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Treatment Failure
Substances
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Antidotes
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Antineoplastic Agents
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Diuretics
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Furosemide
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Leucovorin
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Methotrexate