[TNF]

Gan To Kagaku Ryoho. 1997 Sep;24(11):1486-94.
[Article in Japanese]

Abstract

TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified biogenetically. These mutants show lower adverse effect and higher antitumor activity. Furthermore, TNF gene transduction into lymphocytes and tumor cells shows a decrease in tumorigenicity and enhancement of host immunogenicity. This approach appears to be promising for cancer treatment.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / genetics
  • Antineoplastic Agents
  • Apoptosis
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy
  • Receptors, Tumor Necrosis Factor* / chemistry
  • Receptors, Tumor Necrosis Factor* / classification
  • Receptors, Tumor Necrosis Factor* / genetics
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Signal Transduction
  • Tumor Necrosis Factor-alpha* / genetics
  • Tumor Necrosis Factor-alpha* / physiology

Substances

  • Antigens, CD
  • Antineoplastic Agents
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factor-alpha