Abstract
TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified biogenetically. These mutants show lower adverse effect and higher antitumor activity. Furthermore, TNF gene transduction into lymphocytes and tumor cells shows a decrease in tumorigenicity and enhancement of host immunogenicity. This approach appears to be promising for cancer treatment.
MeSH terms
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Animals
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Antigens, CD / chemistry
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Antigens, CD / genetics
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Antineoplastic Agents
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Apoptosis
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Humans
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Pancreatic Neoplasms / pathology
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Pancreatic Neoplasms / therapy
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Receptors, Tumor Necrosis Factor* / chemistry
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Receptors, Tumor Necrosis Factor* / classification
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Receptors, Tumor Necrosis Factor* / genetics
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Signal Transduction
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Tumor Necrosis Factor-alpha* / genetics
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Tumor Necrosis Factor-alpha* / physiology
Substances
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Antigens, CD
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Antineoplastic Agents
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Tumor Necrosis Factor-alpha