Abstract
1,3-Dimethylbarbituric acid was used as a versatile precursor for the preparation of annelated pyranopyrimidines 2 and 3a-c besides pyrrolopyrimidine 12. The isolated pyrazolopyrimidines 8a-c and 10 and fused pyrazolopyrimidines 14a-d were also synthesized. In addition the new obtained pyrimidoheterocycles were subjected to bacterial testings.
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / toxicity
-
Bacillus subtilis / drug effects
-
Bacteria / drug effects*
-
Escherichia coli / drug effects
-
Magnetic Resonance Spectroscopy
-
Mice
-
Microbial Sensitivity Tests
-
Pyrimidines / chemical synthesis*
-
Pyrimidines / pharmacology
-
Pyrimidines / toxicity
-
Spectrophotometry, Infrared
Substances
-
Anti-Bacterial Agents
-
Pyrimidines