1,3-Dimethylisoguanine, a new purine from the marine sponge Amphimedon viridis

C C Chehade; R L Dias; R G Berlinck; A G Ferreira; L V Costa; M Rangel; E L Malpezzi; J C de Freitas; E Hajdu

doi:10.1021/np970021f

1,3-Dimethylisoguanine, a new purine from the marine sponge Amphimedon viridis

J Nat Prod. 1997 Jul;60(7):729-31. doi: 10.1021/np970021f.

Authors

C C Chehade¹, R L Dias, R G Berlinck, A G Ferreira, L V Costa, M Rangel, E L Malpezzi, J C de Freitas, E Hajdu

Affiliation

¹ Instituto de Química de São Carlos, Universidade de São Paulo, Brazil.

PMID: 9249981
DOI: 10.1021/np970021f

Abstract

A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electric Stimulation
Guanine / analogs & derivatives*
Guanine / chemistry
Guanine / isolation & purification
Guanine / pharmacology
Guinea Pigs
In Vitro Techniques
Muscle Contraction / drug effects
Muscle Contraction / physiology
Porifera / chemistry*

Substances

1,3-dimethylisoguanine
Guanine