In vivo effect of pachymatismin, a new marine glycoprotein, on a human non-small-cell lung carcinoma

In Vivo. 1997 Mar-Apr;11(2):185-8.

Abstract

Pachymatismin is a novel glycoprotein extracted from a marine sponge, which has an antiproliferative effect in vitro on cells from a human non-small-cell bronchopulmonary carcinoma (NSCLC-N6). The drug blocks irreversibly the cells in the G0/G1 phase of the cell cycle. Here, we investigate the antitumor activity of pachymatismin against this cell line. Tumor growth was studied after three weeks treatment of nude mice by different doses of pachymatismin. A significant decrease in tumor growth was observed.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Biological Factors / pharmacology*
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Glycoproteins / pharmacology*
  • Humans
  • Injections, Intravenous
  • Intercellular Signaling Peptides and Proteins
  • Lung Neoplasms / drug therapy*
  • Mice
  • Mice, Nude
  • Porifera / chemistry*
  • Transplantation, Heterologous
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / transplantation

Substances

  • Antineoplastic Agents
  • Biological Factors
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • pachymatismin protein, Pachymatisma johnstonii