Garsubellin A, a novel polyprenylated phloroglucin derivative, increasing choline acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures

Y Fukuyama; A Kuwayama; H Minami

doi:10.1248/cpb.45.947

Garsubellin A, a novel polyprenylated phloroglucin derivative, increasing choline acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures

Chem Pharm Bull (Tokyo). 1997 May;45(5):947-9. doi: 10.1248/cpb.45.947.

Authors

Y Fukuyama¹, A Kuwayama, H Minami

Affiliation

¹ Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.

PMID: 9178529
DOI: 10.1248/cpb.45.947

Abstract

Garsubellin A (1), a novel polyprenylated phloroglucin derivative, has been isolated from the wood of Garcinia subelliptica and its structure has been elucidated by spectroscopic analyses. Compound 1 could increase the ChAT activity at 10 microM in P10 rat septal neuron cultures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / cytology
Brain / drug effects
Brain / enzymology*
Choline O-Acetyltransferase / metabolism*
Magnetic Resonance Spectroscopy
Neurons / drug effects
Neurons / enzymology*
Plants, Medicinal / chemistry*
Rats
Stimulation, Chemical
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Terpenes
garsubellin A
Choline O-Acetyltransferase