3-Epi-aplykurodinone B, a new degraded sterol from Aplysia fasciata

J Nat Prod. 1997 May;60(5):488-9. doi: 10.1021/np9607464.

Abstract

The anaspidean mollusk Aplysia fasciata from Río San Pedro (Cádiz, Spain) contains the known degraded sterols aplykurodinone B (2) and aplykurodin B (4) together with the new 3-epi-aplykurodinone B (5). The structure of 5 was elucidated by interpretation of spectral data, and its relative stereochemistry was established using NOEDS experiments. The new compound 5 exhibited cytotoxicity against four tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Aplysia / metabolism*
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Humans
  • Indans / isolation & purification*
  • Indans / pharmacology
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Spectrophotometry, Infrared
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Indans
  • Lactones
  • aplykurodinone B