Abstract
The anaspidean mollusk Aplysia fasciata from Río San Pedro (Cádiz, Spain) contains the known degraded sterols aplykurodinone B (2) and aplykurodin B (4) together with the new 3-epi-aplykurodinone B (5). The structure of 5 was elucidated by interpretation of spectral data, and its relative stereochemistry was established using NOEDS experiments. The new compound 5 exhibited cytotoxicity against four tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Aplysia / metabolism*
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Humans
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Indans / isolation & purification*
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Indans / pharmacology
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Spectrophotometry, Infrared
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Indans
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Lactones
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aplykurodinone B