Abstract
Effects of a combination of medetomidine-ketamine as a chemical restraint and antagonistic effects of atipamezole on this combination were investigated in 5 lions. The medetomidine (47.6-58.4 micrograms/kg) and ketamine (1.9-5.7 mg/kg) combination provided complete immobilization with good analgesia and muscle relaxation in 4 lions, while one lioness was poorly sedated by medetomidine, and additional injections of medetomidine and ketamine were required. The duration of anesthesia seemed to be much longer than one hour in 4 of the lions. Atipamezole, at four times the preceding dose of medetomidine, provided a smooth recovery and animals were able to stand up 17-61 min after its injection. Side effects were limited to vomiting after walking in 3 of 5 lions.
MeSH terms
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Anesthetics, Dissociative / administration & dosage*
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Anesthetics, Dissociative / adverse effects
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Anesthetics, Dissociative / pharmacology
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Animals
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Body Temperature / drug effects
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Body Temperature / physiology
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Dose-Response Relationship, Drug
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Drug Combinations
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Female
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Heart Rate / drug effects
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Heart Rate / physiology
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Hypnotics and Sedatives / administration & dosage*
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Hypnotics and Sedatives / adverse effects
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Hypnotics and Sedatives / pharmacology
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Imidazoles / administration & dosage*
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Imidazoles / adverse effects
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Imidazoles / pharmacology
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Immobilization*
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Ketamine / administration & dosage*
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Ketamine / adverse effects
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Ketamine / pharmacology
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Lions / physiology*
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Male
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Medetomidine
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Respiration / drug effects
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Respiration / physiology
Substances
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Anesthetics, Dissociative
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Drug Combinations
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Hypnotics and Sedatives
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Imidazoles
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Ketamine
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Medetomidine