Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo)

P Valenti; A Rampa; A Bisi; F Belluti; P Da Re; M Carrara; L Cima

Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo)

Anticancer Drug Des. 1997 Mar;12(2):137-44.

Authors

P Valenti¹, A Rampa, A Bisi, F Belluti, P Da Re, M Carrara, L Cima

Affiliation

¹ Department of Pharmaceutical Sciences, University of Bologna, Italy.

PMID: 9113068

Abstract

Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / pharmacology*
Colonic Neoplasms / drug therapy*
Coumarins / chemical synthesis*
Coumarins / pharmacology*
Drug Screening Assays, Antitumor
Humans
Isomerism
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Coumarins
geiparvarin