Prothrombin activation fragment 1 + 2 and thrombin-antithrombin-III complexes in plasma of patients with essential arterial hypertension

Pol J Pharmacol. 1996 Mar-Apr;48(2):233-5.

Abstract

Prothrombin activation fragment 1 + 2 (F1 + 2) and thrombin-antithrombin-III complexes (TAT) were measured in plasma of 34 patients with newly diagnosed essential hypertension. The patients with hypertension showed an increase in both F1 + 2 and TAT concentrations. The obtained results point to the intravascular thrombin generation in very early stages of essential hypertension.

MeSH terms

  • Adult
  • Antithrombin III / metabolism*
  • Female
  • Humans
  • Hypertension / blood*
  • Male
  • Middle Aged
  • Peptide Fragments / metabolism*
  • Peptide Hydrolases / metabolism*
  • Prothrombin / metabolism*

Substances

  • Peptide Fragments
  • antithrombin III-protease complex
  • prothrombin fragment 1.2
  • Antithrombin III
  • Prothrombin
  • Peptide Hydrolases