Cytotoxicity and electron microscopy of cell death induced by goniothalamin

Planta Med. 1997 Feb;63(1):81-3. doi: 10.1055/s-2006-957611.

Abstract

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Death / drug effects*
  • Humans
  • Mice
  • Microscopy, Electron
  • Pyrones / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Pyrones
  • goniothalamin