Selective carriers of norepinephrine and ammonium ions: ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit

Bioorg Med Chem. 1997 Feb;5(2):363-71. doi: 10.1016/s0968-0896(96)00250-7.

Abstract

Ionophoric properties of dipyrazolic crowns and podands containing a 1,3-bis(1H-pyrazol-1-yl)propane unit in their structure are described. They show selectivity of ammonium vs alkali cations and interesting norepinephrine transport rates. A molecular modelling study has been used to elucidate the superstructures of the crown and ammonium cation complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Esters / chemistry*
  • Ionophores / chemistry*
  • Models, Molecular
  • Norepinephrine / chemistry*
  • Pyrazoles / chemistry*
  • Quaternary Ammonium Compounds / chemistry*

Substances

  • Esters
  • Ionophores
  • Pyrazoles
  • Quaternary Ammonium Compounds
  • Norepinephrine