Heterocyclic analogues of quinone methide: preparation and cytotoxicity of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives

Chem Pharm Bull (Tokyo). 1997 Jan;45(1):143-7. doi: 10.1248/cpb.45.143.

Abstract

A series of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives was prepared and characterized as heterocyclic analogues of quinone methide. These compounds showed some cytotoxicity to cancer cells, but were ineffective in an in vivo test against murine leukemia L1210.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Drug Screening Assays, Antitumor
  • Indolequinones*
  • Indoles / chemical synthesis*
  • Leukemia L1210 / drug therapy
  • Male
  • Mice
  • Mitomycin / pharmacology
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology*
  • Quinones / chemical synthesis*
  • Tumor Cells, Cultured / drug effects

Substances

  • Indolequinones
  • Indoles
  • Pyrazoles
  • Quinones
  • quinone methide
  • Mitomycin