Abstract
We report a case of severe anaphylactic shock during a cardiac operation that occurred as a consequence of aprotinin readministration in the presence of preformed aprotinin-specific antibodies. Both immunoglobulin G (3 hours) and immunoglobulin E (5 minutes) antibody levels dropped early after the clinical event. Despite their possibly limited clinical significance, we still recommend the conductance of specific antibody screening tests before readministration of aprotinin.
MeSH terms
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Aged
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Anaphylaxis / chemically induced*
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Anaphylaxis / immunology
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Antibodies / immunology
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Aprotinin / administration & dosage
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Aprotinin / adverse effects*
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Aprotinin / immunology
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Female
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Heart Valve Prosthesis
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Hemostatics / administration & dosage
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Hemostatics / adverse effects*
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Hemostatics / immunology
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Humans
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Immunoglobulin E / immunology
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Immunoglobulin G / immunology
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Intraoperative Complications / immunology*
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Time Factors
Substances
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Antibodies
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Hemostatics
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Immunoglobulin G
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Immunoglobulin E
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Aprotinin