Anaphylactic shock after aprotinin reexposure: time course of aprotinin-specific antibodies

Ann Thorac Surg. 1997 Jan;63(1):242-4. doi: 10.1016/s0003-4975(96)01062-4.

Abstract

We report a case of severe anaphylactic shock during a cardiac operation that occurred as a consequence of aprotinin readministration in the presence of preformed aprotinin-specific antibodies. Both immunoglobulin G (3 hours) and immunoglobulin E (5 minutes) antibody levels dropped early after the clinical event. Despite their possibly limited clinical significance, we still recommend the conductance of specific antibody screening tests before readministration of aprotinin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anaphylaxis / chemically induced*
  • Anaphylaxis / immunology
  • Antibodies / immunology
  • Aprotinin / administration & dosage
  • Aprotinin / adverse effects*
  • Aprotinin / immunology
  • Female
  • Heart Valve Prosthesis
  • Hemostatics / administration & dosage
  • Hemostatics / adverse effects*
  • Hemostatics / immunology
  • Humans
  • Immunoglobulin E / immunology
  • Immunoglobulin G / immunology
  • Intraoperative Complications / immunology*
  • Time Factors

Substances

  • Antibodies
  • Hemostatics
  • Immunoglobulin G
  • Immunoglobulin E
  • Aprotinin