Glipizide is a second generation of sulphonylurea compound, effective in lowering of blood glucose, well-tolerated as well as safe during long-term treatment. Glipizide is the agent characterized by rapid pharmacological action. It is indicated both in monotherapy and combined treatment with insulin or biguanides. This drug is particularly indicated in diabetes treatment in elderly patients due to short time of action as well as lack of hyperinsulinemic effect. Data in literature suggest that glipizide combined with insulin is much more effective in the induction of remission in recent diagnosed diabetes when compared to intensive insulin therapy.