Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets

J Med Chem. 1996 Dec 20;39(26):5031-4. doi: 10.1021/jm960674d.

Authors

H T Lee¹, D R Sliskovic, J A Picard, B D Roth, W Wierenga, J L Hicks, R F Bousley, K L Hamelehle, R Homan, C Speyer, R L Stanfield, B R Krause

Affiliation

¹ Department of Medicinal Chemistry, Radiochemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.

PMID: 8978833
DOI: 10.1021/jm960674d

No abstract available

MeSH terms

Acetamides
Acetates*
Animals
Anticholesteremic Agents / chemistry
Anticholesteremic Agents / pharmacology*
Diet
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Rabbits
Rats
Sterol O-Acyltransferase / antagonists & inhibitors*
Sulfonamides
Sulfonic Acids / chemistry
Sulfonic Acids / pharmacology*

Substances

Acetamides
Acetates
Anticholesteremic Agents
Enzyme Inhibitors
Sulfonamides
Sulfonic Acids
avasimibe
Sterol O-Acyltransferase