Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

Gen Pharmacol. 1996 Mar;27(2):199-204. doi: 10.1016/0306-3623(95)02023-3.

Abstract

Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apomorphine / pharmacology
  • Behavior, Animal / drug effects*
  • Central Nervous System Stimulants / antagonists & inhibitors*
  • Dopamine Agonists / pharmacology
  • Homing Behavior
  • Male
  • Methamphetamine / antagonists & inhibitors*
  • Mice
  • Motor Activity / drug effects
  • Panax*
  • Plants, Medicinal*
  • Saponins / pharmacology*

Substances

  • Central Nervous System Stimulants
  • Dopamine Agonists
  • Saponins
  • Methamphetamine
  • Apomorphine