Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder

L J Adams; J Salmon; J A Donald; P B Mitchell; P R Schofield

doi:10.1002/(SICI)1096-8628(19960920)67:5<485::AID-AJMG9>3.0.CO;2-J

Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder

Am J Med Genet. 1996 Sep 20;67(5):485-7. doi: 10.1002/(SICI)1096-8628(19960920)67:5<485::AID-AJMG9>3.0.CO;2-J.

Authors

L J Adams¹, J Salmon, J A Donald, P B Mitchell, P R Schofield

Affiliation

¹ School of Psychiatry, University of New South Wales, Little Bay, New South Wales, Australia.

PMID: 8886167
DOI: 10.1002/(SICI)1096-8628(19960920)67:5<485::AID-AJMG9>3.0.CO;2-J

Abstract

To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Australia
Bipolar Disorder / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 6*
Disease Susceptibility
Genes, Dominant
Genes, Recessive
Genetic Linkage*
Genetic Markers*
Humans
Lod Score
Models, Genetic
Psychotic Disorders / genetics
Schizophrenia / genetics*

Substances

Genetic Markers