Abstract
We previously reported the production of anti-IRS-1 monoclonal antibodies against human IRS-1 C-terminal portion. One of anti IRS-1 monoclonal antibodies, 6G5, was found to immunologically cross-react with IRS-2, which has been reported recently. The data presented here provide information arising from the use of the anti-IRS-1 MAb, 6G5; this MAb was found to be a useful reagent in studying the functional role of IRSs in the insulin-signaling system.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antibody Specificity*
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Cross Reactions
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Humans
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Insulin Receptor Substrate Proteins
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Intracellular Signaling Peptides and Proteins
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Mice
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Phosphatidylinositol 3-Kinases
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Phosphopeptides / immunology
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Phosphoproteins / deficiency
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Phosphoproteins / immunology*
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Phosphotransferases (Alcohol Group Acceptor) / analysis
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Recombinant Proteins / immunology
Substances
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Antibodies, Monoclonal
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IRS1 protein, human
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IRS2 protein, human
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Insulin Receptor Substrate Proteins
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Intracellular Signaling Peptides and Proteins
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Irs1 protein, mouse
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Irs2 protein, mouse
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Phosphopeptides
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Phosphoproteins
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Recombinant Proteins
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Phosphatidylinositol 3-Kinases
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Phosphotransferases (Alcohol Group Acceptor)