Viral inhibition of apoptosis

Trends Microbiol. 1996 Aug;4(8):312-7. doi: 10.1016/0966-842x(96)10047-0.

Abstract

Viral propagation is limited both by the host immune response and by apoptosis of infected cells. Viruses circumvent apoptosis by different mechanisms: direct inhibition of particular proteases involved in cell death, stimulation of anti-death pathways or regulation of the activity of transcription factors monitoring cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors
  • Gene Expression Regulation
  • Models, Biological
  • Proto-Oncogene Proteins c-bcl-2
  • Transcription, Genetic
  • Viruses / growth & development*
  • Viruses / metabolism

Substances

  • Cysteine Proteinase Inhibitors
  • Proto-Oncogene Proteins c-bcl-2
  • Cysteine Endopeptidases