Side reactions in the pyroglutamic acid-7-amino-4-methylcoumarin synthesis

Int J Pept Protein Res. 1996 Jul;48(1):56-8. doi: 10.1111/j.1399-3011.1996.tb01106.x.

Abstract

N-Formylpyroglutamic acid-7-amido-4-methylcoumarine and pyroglutamyl-pyroglutamic acid-7-amido-4-methylcoumarin are the major products in the synthesis of pyroglutamic acid-7-amido-4-methylcoumarin by phosphorus pentachloride in dimethylformamide and dicyclohexylcarbodiimide under pyridine activation.

MeSH terms

  • Chlorides / chemistry
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry*
  • Dicyclohexylcarbodiimide / chemistry
  • Phosphorus / chemistry
  • Phosphorus Compounds*
  • Pyrrolidonecarboxylic Acid / chemistry*

Substances

  • Chlorides
  • Coumarins
  • Phosphorus Compounds
  • pyroglutamic acid 7-amino-4-methylcoumarin
  • Phosphorus
  • Dicyclohexylcarbodiimide
  • phosphorus chloride
  • 7-amino-4-methylcoumarin
  • Pyrrolidonecarboxylic Acid