A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation

Biochem Mol Biol Int. 1996 Jul;39(4):747-54. doi: 10.1080/15216549600201831.

Abstract

A full-length cDNA clone encoding a zinc finger protein was isolated and sequenced. This full-length clone consists of 728 bp and has a predicted open reading frame (ORF) encoding 208 amino acids. The ORF of this polypeptide codes for the human cysteine-rich protein 2 (HCRP2) and has an amino acid sequence that is 92.8% identical to its rat homolog (RCRP2). HCRP2 was mapped to chromosome 14q32, which is a hot spot of translocation in tumor development, by fluorescent in situ hybridization (FISH).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 14*
  • DNA, Complementary / chemistry
  • Humans
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Rats
  • Sequence Alignment
  • Translocation, Genetic*

Substances

  • DNA, Complementary

Associated data

  • GENBANK/U36190