Abstract
A "one-pot reaction" has been used for simultaneous protection of amino and O6-function of deoxyguanosine. N-(4-bromobutyl) phthalimide used for O6-protection generates an alkylamino function after mild base hydrolysis. Two sequences d(GGA) and d(GGATCC) have been synthesised with all protected guanosine units. Similarly, 2-(vinyl)pyridine has also been used for O6-protection following the same strategy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Deoxyguanosine / chemical synthesis
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Deoxyguanosine / chemistry
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Guanosine / chemical synthesis*
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Guanosine / chemistry*
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Indicators and Reagents
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Methods
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Molecular Structure
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Oligodeoxyribonucleotides / chemical synthesis
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Oligodeoxyribonucleotides / chemistry
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Phthalimides
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Pyridines
Substances
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Indicators and Reagents
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Oligodeoxyribonucleotides
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Phthalimides
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Pyridines
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Guanosine
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2-vinylpyridine
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Deoxyguanosine