Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium

FEMS Microbiol Lett. 1996 Sep 1;142(2-3):155-60. doi: 10.1111/j.1574-6968.1996.tb08423.x.

Abstract

Heat treatment of Salmonella typhimurium results in cell death, which coincides with a significant reduction of the cellular content of 16S ribosomal RNA. It is suggested that the degradation of ribosomal RNA is a direct cause of cell death. This conclusion is based on the observation of carbon-starved and magnesium-supplemented cells, which survive heat treatment much better, and which also maintain stable levels of ribosomal RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / metabolism
  • Cell Death*
  • DNA Probes / genetics
  • Hot Temperature / adverse effects*
  • In Situ Hybridization
  • Magnesium / metabolism
  • RNA, Ribosomal, 16S / genetics
  • RNA, Ribosomal, 16S / metabolism*
  • RNA, Ribosomal, 23S / genetics
  • RNA, Ribosomal, 23S / metabolism*
  • Salmonella typhimurium / metabolism*

Substances

  • DNA Probes
  • RNA, Ribosomal, 16S
  • RNA, Ribosomal, 23S
  • Carbon
  • Magnesium