Abstract
Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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DNA / metabolism
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Humans
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Ligands
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Models, Molecular
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Molecular Structure
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Protein Conformation
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / metabolism*
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Receptors, Cytoplasmic and Nuclear / chemistry
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Transcriptional Activation
Substances
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Ligands
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Receptors, Cell Surface
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Receptors, Cytoplasmic and Nuclear
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DNA