In-vitro evaluation of the antimicrobial activities of Enantia chlorantha Oliv. extractives

J O Moody; S F Bloomfield; P J Hylands

In-vitro evaluation of the antimicrobial activities of Enantia chlorantha Oliv. extractives

Afr J Med Med Sci. 1995 Sep;24(3):269-73.

Authors

J O Moody¹, S F Bloomfield, P J Hylands

Affiliation

¹ Chelsea Department of Pharmacy, King's College, University of London, United Kingdom.

PMID: 8798963

Abstract

A bioactivity-directed fractionation of the root-and stem-barks of Enantia chlorantha resulted in the isolation of palmatine chloride 1 and jatrorrhizine chloride 2 as the major antimicrobial constituents. MIC determinations indicated that these compounds were superior to those of well established broad spectrum antibiotics against some of the organisms used.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Berberine Alkaloids / analysis
Biological Availability
Drug Evaluation, Preclinical
Humans
Medicine, African Traditional*
Microbial Sensitivity Tests
Nigeria
Plants, Medicinal / chemistry
Plants, Medicinal / physiology*

Substances

Anti-Infective Agents
Berberine Alkaloids
palmatine