[Kinetic study of the cyclization of the addition compound of ethyl mercaptoacetate on benzylideneacetophenone]

C Guinchard; A Dankar; M F Mercier; A Xicluna; J F Robert

[Kinetic study of the cyclization of the addition compound of ethyl mercaptoacetate on benzylideneacetophenone]

Ann Pharm Fr. 1996;54(3):103-8.

[Article in French]

Authors

C Guinchard¹, A Dankar, M F Mercier, A Xicluna, J F Robert

Affiliation

¹ Equipe de Chimie Thérapeutique, UFR des Sciences, Médicales et Pharmaceutiques, Besançon.

PMID: 8794578

Abstract

The study of the kinetic of cyclisation reaction of the additional compound of the mercaptoacetic ethylester on a benzylideneacetophenone was proposed. With the chromatography a retro-Michael reaction was obtained. The H NMR alone permitted to show the order 1 for the kinetic of cyclization and according to the amine used like reaction catalyst, two diastereoisomers could be formed.

Publication types

English Abstract

MeSH terms

Chalcone / administration & dosage
Chalcone / pharmacokinetics*
Chromatography, High Pressure Liquid
Cyclization
Drug Combinations
In Vitro Techniques
Magnetic Resonance Spectroscopy
Mass Spectrometry
Stereoisomerism
Thioglycolates / administration & dosage
Thioglycolates / pharmacokinetics*

Substances

Drug Combinations
Thioglycolates
Chalcone
2-mercaptoacetate