Antibacterial neoclerodane diterpenoids from Ajuga lupulina

J Nat Prod. 1996 Jul;59(7):668-70. doi: 10.1021/np960385s.

Abstract

The whole plants of Ajuga lupulina afforded five compounds, including three new clerodane diterpenes, lupulins A-C (1-3), whose structures were elucidated by spectral methods. Among these compounds, lupulins A (1) and B (2) as well as the acid hydrolysate (5) of lupulin D (4) showed antibacterial activities against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemistry
  • Acetals / isolation & purification*
  • Acetals / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects*
  • China
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Escherichia coli / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Plants, Medicinal / chemistry*
  • Pseudomonas aeruginosa / drug effects
  • Spectroscopy, Fourier Transform Infrared
  • Staphylococcus aureus / drug effects
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Acetals
  • Anti-Bacterial Agents
  • Diterpenes
  • Triterpenes