Abstract
A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic activity but improves the potency and selectivity for chronotropism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / chemical synthesis*
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Calcium Channel Blockers / pharmacology
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Cardiotonic Agents / chemical synthesis*
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Cardiotonic Agents / pharmacology
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Dihydropyridines / chemical synthesis*
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Dihydropyridines / pharmacology
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Female
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Guinea Pigs
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Heart Atria / drug effects
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Calcium Channel Blockers
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Cardiotonic Agents
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Dihydropyridines
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Organophosphorus Compounds