Fluoxetin-induced pulmonary granulomatosis

E de Kerviler; J Trédaniel; G Revlon; O Groussard; G Zalcman; J M Ortoli; M Espié; A Hirsch; J Frija

doi:10.1183/09031936.96.09030615

Fluoxetin-induced pulmonary granulomatosis

Eur Respir J. 1996 Mar;9(3):615-7. doi: 10.1183/09031936.96.09030615.

Authors

E de Kerviler¹, J Trédaniel, G Revlon, O Groussard, G Zalcman, J M Ortoli, M Espié, A Hirsch, J Frija

Affiliation

¹ Service de Radiologie, Hôpital Saint-Louis, Paris, France.

PMID: 8730028
DOI: 10.1183/09031936.96.09030615

Abstract

A patient treated with fluoxetin for a manic depressive disorder developed pulmonary inflammatory nodules with noncaseating giant cell granulomas, interstitial pneumonia and non-necrotizing vasculitis, whilst remaining asymptomatic. A progressive resolution of pulmonary nodules occurred after withdrawal of the offending agent, and the chest radiograph returned to normal in 9 months. The diagnosis was assessed by an open lung biopsy.

Publication types

Case Reports

MeSH terms

Antidepressive Agents, Second-Generation / adverse effects*
Antidepressive Agents, Second-Generation / therapeutic use
Depressive Disorder / drug therapy
Diagnosis, Differential
Female
Fluoxetine / adverse effects*
Fluoxetine / therapeutic use
Granuloma, Giant Cell / chemically induced*
Granuloma, Giant Cell / diagnosis
Granuloma, Giant Cell / physiopathology
Humans
Lung Diseases / chemically induced*
Lung Diseases / diagnosis
Lung Diseases / physiopathology
Middle Aged

Substances

Antidepressive Agents, Second-Generation
Fluoxetine