Subacute encephalopathic toxicity of cisplatin

Lung Cancer. 1995 Dec;13(3):305-9. doi: 10.1016/0169-5002(95)00503-x.

Abstract

Acute blindness or seizures are usually the first signs of central neurotoxicity from cisplatin. We report a case of subacute neurotoxicity caused by cisplatin. Progressive encephalopathy and partial loss of vision were the main observed signs. This condition was completely reversible upon cisplatin discontinuation, as is usually the case with acute central neurotoxicity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / pathology
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Blindness / chemically induced*
  • Brain Diseases / chemically induced*
  • Brain Diseases / physiopathology
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Etoposide / administration & dosage
  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Middle Aged
  • Neoplasm Staging
  • Ondansetron / administration & dosage

Substances

  • Granulocyte Colony-Stimulating Factor
  • Ondansetron
  • Etoposide
  • Cisplatin