Abstract
To investigate the effects of the acute administration of aminophylline and nitroglycerin on effort ischemia, 20 patients with syndrome X underwent 3 bicycle exercise tests after sublingual nitroglycerin (0.3 mg) and after 90 minutes of oral administration of aminophylline (400 mg). Compared with the basal test, only aminophylline induced a significant increase in the time to ischemic threshold and to angina; these findings support the potential therapeutic role of this adenosine receptor blocking agents and suggest a possible role of "steal phenomenon" in the pathogenesis of effort angina in patients with syndrome X.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Aminophylline / administration & dosage
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Aminophylline / pharmacology*
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Cardiotonic Agents / administration & dosage
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Cardiotonic Agents / pharmacology*
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Exercise Test
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Exercise Tolerance / drug effects*
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Female
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Humans
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Male
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Microvascular Angina / physiopathology*
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Middle Aged
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Nitroglycerin / administration & dosage
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Nitroglycerin / pharmacology*
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Receptors, Purinergic P1 / drug effects
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Time Factors
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Vasodilator Agents / administration & dosage
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Vasodilator Agents / pharmacology*
Substances
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Cardiotonic Agents
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Receptors, Purinergic P1
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Vasodilator Agents
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Aminophylline
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Nitroglycerin