Low incidence of serotonin-induced occlusive coronary artery spasm in patients with recent myocardial infarction

R Mongiardo; M L Finocchiaro; J Beltrame; C Pristipino; A Lombardo; D Cianflone; M A Mazzari; A Maseri

doi:10.1016/s0002-9149(96)00230-5

Low incidence of serotonin-induced occlusive coronary artery spasm in patients with recent myocardial infarction

Am J Cardiol. 1996 Jul 1;78(1):84-7. doi: 10.1016/s0002-9149(96)00230-5.

Authors

R Mongiardo¹, M L Finocchiaro, J Beltrame, C Pristipino, A Lombardo, D Cianflone, M A Mazzari, A Maseri

Affiliation

¹ Institute of Cardiology, Catholic University of Rome, Italy.

PMID: 8712124
DOI: 10.1016/s0002-9149(96)00230-5

Abstract

Intracoronary infusion of serotonin has been reported to induce varying degrees of coronary vasoconstriction in different coronary syndromes, but it has never been studied in patients after myocardial infarction. In patients with recent myocardial infarction, we found a low incidence (11%) of serotonin-induced occlusive spasm only in the infarct-related artery (IRA), and a significantly higher vasoconstriction in the distal segment of the IRA than in the same segment of the non-IRA.

Publication types

Comparative Study

MeSH terms

Cardiac Catheterization
Coronary Angiography
Coronary Vasospasm / physiopathology*
Coronary Vessels / drug effects
Coronary Vessels / physiopathology
Female
Humans
Infusions, Intra-Arterial
Isosorbide Dinitrate / administration & dosage
Isosorbide Dinitrate / pharmacology
Male
Middle Aged
Myocardial Infarction / physiopathology*
Serotonin / administration & dosage
Serotonin / pharmacology*
Vasoconstriction / drug effects
Vasodilator Agents / administration & dosage
Vasodilator Agents / pharmacology

Substances

Vasodilator Agents
Serotonin
Isosorbide Dinitrate