Antagonizing the differentiation and functions of human T helper type 2 cells

Curr Opin Immunol. 1995 Dec;7(6):771-8. doi: 10.1016/0952-7915(95)80046-8.

Abstract

Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Humans
  • Immunoglobulin E / biosynthesis
  • Immunoglobulin E / immunology
  • Interferon-gamma / biosynthesis
  • Interleukin-13 / biosynthesis
  • Interleukin-13 / immunology
  • Interleukin-4 / biosynthesis
  • Interleukin-4 / immunology
  • Lymphocyte Activation*
  • Mice
  • Mice, SCID
  • Models, Immunological
  • Receptors, Interleukin / antagonists & inhibitors*
  • Th2 Cells / immunology*
  • Th2 Cells / metabolism*

Substances

  • Interleukin-13
  • Receptors, Interleukin
  • Interleukin-4
  • Immunoglobulin E
  • Interferon-gamma