Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3

Gene. 1996 May 8;170(2):287-8. doi: 10.1016/0378-1119(95)00864-0.

Abstract

Using a cDNA probe, two genomic clones were obtained encoding the human tissue inhibitor of metalloproteinases-3 (TIMP-3). Analysis of these clones showed that they contained four distal exons and three introns of the gene. Although the intron-exon structure is similar to that of the timp1 gene, the first intron of the timp3 gene is much longer, being at least 17.5 kb in size.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA
  • Humans
  • Molecular Sequence Data
  • Proteins / genetics*
  • Tissue Inhibitor of Metalloproteinase-3

Substances

  • Proteins
  • Tissue Inhibitor of Metalloproteinase-3
  • DNA

Associated data

  • GENBANK/U38952
  • GENBANK/U38953
  • GENBANK/U38954
  • GENBANK/U38955